Results: A total of 78 patients with similar demographic and disease characteristics were enrolled. There was a significant reduction in ICU admissions (2 out of 39 vs. 11 out of 39, P = 0.006), intubation (1 out of 39 vs. 9 out of 39, P = 0.007) and death (0 vs. 5, P = 0.027) in the bromhexine treated group compared to the standard group. No patients were withdrawn from the study because of adverse effects.
转Bioimpacts. 2020;10(4): 209-215
Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial
评论: 可以用于预防也可以治疗, 药理与再生元抗体药接近, 都将病毒挡在细胞之外。很好, 但研究病人数目少了些。不过, 实验一般都从人数少做起。我不是医生。
Bromhexine是TMPRSS2抑制剂,可能减少新冠死亡率
Bromhexine是TMPRSS2抑制剂,可能减少新冠死亡率
上次由 ychen 在 周日 10月 18, 2020 5:07 pm，总共编辑 4 次。
Re: Bromhexine是TMPRSS2抑制剂,可能减少新冠死亡率
Biochimie
Volume 142, November 2017, Pages 1-10
Mini-review
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
Author links open overlay panelLi WenShenaWenZhanga
https://doi.org/10.1016/j.biochi.2017.07.016
Get rights and content
Highlights
•
The structure and physiological function of TMPRSS2.
•
TMPRSS2 is involved in proteolytic activation of influenza virus and coronavirus.
•
Development of therapeutics targeting TMPRSS2.
Abstract
Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2.
Volume 142, November 2017, Pages 1-10
Mini-review
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
Author links open overlay panelLi WenShenaWenZhanga
https://doi.org/10.1016/j.biochi.2017.07.016
Get rights and content
Highlights
•
The structure and physiological function of TMPRSS2.
•
TMPRSS2 is involved in proteolytic activation of influenza virus and coronavirus.
•
Development of therapeutics targeting TMPRSS2.
Abstract
Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2.