Furin inhibitor 新冠病毒的抑制剂？
Furin inhibitor 新冠病毒的抑制剂？
新近发表的论文比较了新冠病毒S蛋白的胺基酸差异, 发现在S1与S2之间增加了一个Furin酶切点, 可能因此加强了病毒侵入人体细胞的能力。是否可以采用Furin 抑制剂阻断病毒的这种攻击力？
Re: Furin inhibitor 新冠病毒的抑制剂？
One such mutation
could be the insertion of the amino acid residues PRRA near the S1/S2 junction which induces a
furin cleavage motif. The secondary requirement for entry into the host cell is proteolytic
cleavage of the S1/S2 domains in order to mediate membrane fusion post ACE2 binding 4, and
introduction of the furin cleavage motif may be another factor in nCoV-2019 being able to
replicate in humans (Figure 2).
转
也许缺了furin酶切点, 穿出甲病毒对人攻击力差点。需要实验证明。
could be the insertion of the amino acid residues PRRA near the S1/S2 junction which induces a
furin cleavage motif. The secondary requirement for entry into the host cell is proteolytic
cleavage of the S1/S2 domains in order to mediate membrane fusion post ACE2 binding 4, and
introduction of the furin cleavage motif may be another factor in nCoV-2019 being able to
replicate in humans (Figure 2).
转
也许缺了furin酶切点, 穿出甲病毒对人攻击力差点。需要实验证明。
上次由 ychen 在 周一 2月 17, 2020 2:58 am，总共编辑 1 次。
Re: Furin inhibitor 新冠病毒的抑制剂？
Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-
2019
Matthew C. Wong, BS, 1#
Sara J. Javornik Cregeen, PhD, 1#
Nadim J. Ajami, PhD, 2
Joseph F. Petrosino, PhD, 1*
1Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and
Microbiology, Baylor College of Medicine, Houston, TX 77030 USA
2Program for Innovative Microbiome and Translational Research, Department of Genomic
Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 USA
#These authors contributed equally
*Corresponding author contact
Joseph F. Petrosino
jpetrosi@bcm.edu
SUMMARY
A novel coronavirus (nCoV-2019) was the cause of an outbreak of respiratory illness detected in
Wuhan, Hubei Province, China in December of 2019. Genomic analyses of nCoV-2019 determined a
96% resemblance with a coronavirus isolated from a bat in 2013 (RaTG13); however, the receptor
binding motif (RBM) of these two genomes share low sequence similarity. This divergence suggests a
possible alternative source for the RBM coding sequence in nCoV-2019. We identified high sequence
similarity in the RBM between nCoV-2019 and a coronavirus genome reconstructed from a viral
metagenomic dataset from pangolins possibly indicating a more complex origin for nCoV-2019.
2019
Matthew C. Wong, BS, 1#
Sara J. Javornik Cregeen, PhD, 1#
Nadim J. Ajami, PhD, 2
Joseph F. Petrosino, PhD, 1*
1Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and
Microbiology, Baylor College of Medicine, Houston, TX 77030 USA
2Program for Innovative Microbiome and Translational Research, Department of Genomic
Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 USA
#These authors contributed equally
*Corresponding author contact
Joseph F. Petrosino
jpetrosi@bcm.edu
SUMMARY
A novel coronavirus (nCoV-2019) was the cause of an outbreak of respiratory illness detected in
Wuhan, Hubei Province, China in December of 2019. Genomic analyses of nCoV-2019 determined a
96% resemblance with a coronavirus isolated from a bat in 2013 (RaTG13); however, the receptor
binding motif (RBM) of these two genomes share low sequence similarity. This divergence suggests a
possible alternative source for the RBM coding sequence in nCoV-2019. We identified high sequence
similarity in the RBM between nCoV-2019 and a coronavirus genome reconstructed from a viral
metagenomic dataset from pangolins possibly indicating a more complex origin for nCoV-2019.